中国·威尼斯(5845cc-官方认证)网站-正版App Store下载

2005年9月-2009年6月：武汉大学，药学院，药学，学士
2010年9月-2012年6月：武汉大学，药学院，药物化学，硕士 （导师：洪学传  教授）
2012年9月-2016年11月：华东师范大学，化学与分子工程学院，有机化学，博士 （导师：张俊良  教授）

2017年3月-2017年5月：上海润诺生物科技有限公司，有机合成高级研究员
2017年6月-2021年3月：湖南科技学院，制药工程系，讲师
2021年4月至今：5845cc威斯尼斯人下载，化学系，助理研究员

核苷（酸）的化学修饰与应用

核苷/酸-碳硼烷偶联物的合成与在硼中子俘获治疗（BNCT）中的应用研究

核苷酸化学生物学

1．湖南省自然科学基金青年基金，2018JJ3195，已结题

2．国家自然科学基金青年基金，21801075，已结题

3．上海交通大学医工交叉研究基金，YG2022QN019，已结题

参与青海省基础研究计划、科技援青合作专项——区域处等项目

(20) Tingting Liu, Xingyue Chen, Shah Nawaz Khan, Xiaoxu Li, Bo Kong, Yingjun Zhou, Yangyan Li, Yuhua Ge, Gang Chen*, Xu Deng*, Phytohormone Strigolactams Overcomes Oxaliplatin Resistance in Colorectal Cancer by Blocking the Late-Stage Autophagy to Tip the Metabolic Balance toward Ferroptosis. J. Med. Chem. 2025, 68, 24546-24559. 

(19) Yujie Jiang, Yutong Zhou, Ruoqian Xie, Yangyan Li, Raghunath Bag*, Gang Chen*, Light-Mediated Modification and Manipulation of Nucleic Acids. ChemPhotoChem 2025, e202500098.

(18)  Yangyan Li,*Madiha Butt, Wenhu Bao, Ruoqian Xie, Gang Chen,* Progress in the Functionalization of Purines and Purine Nucleosides by Minisci Reactions Over the Past 50 Years. ChemCatChem 2025, e202401550. 

(17) Yangyan Li,‡ Yutong Zhou,‡ Dazhi Zhou,‡ Yujie Jiang, Madiha Butt, Hui Yang, Yingchuan Que, Zhiming Li,* Gang Chen,* Regioselective Homolytic C²–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction. J. Am. Chem. Soc. 2024, 146, 21428.

(16) Ruoqian Xie, Wanlu Li, Yuhua Ge*, Yutong Zhou, Guolan Xiao, Qin Zhao, Yunxi Han, Yangyan Li, Gang Chen*, Late-stage guanine C8–H alkylation of nucleosides, nucleotides, and oligonucleotides via photo-mediated Minisci reaction. Nat. Commun. 2024, 15, 2549.

(15) Yuhua Ge*, Yijiang Peng, Ruoqian Xie, Yang Luo, Yangyan Li*, Gang Chen*, Visible Light-mediated Late-stage Thioetherification of Mercaptopurine Derivatives. Chem. Eur. J., 2024, 30, e202401774.

(14) Ruoqian Xie, Yunxi Han, Wenhao Luo, Qin Zhao, Yangyan Li, Gang Chen*, Palladium-Catalyzed C–H Olefination for Nucleic Acid Production, Current Protocols, 2023, 3, e829, DOI: 10.1002/cpzl.829.

(13)  Qin Zhao, Ruoqian Xie, Yuxiao Zeng, Wanlu Li, Guolan Xiao, Yangyan Li*, Gang Chen*, Palladium-catalyzed C–H Olefination of Uridine, Deoxyuridine, Uridine Monophosphate and Uridine Analogues, RSC Adv., 2022, 12, 24930. 

(12) Yuhua Ge*, Xingyue Chen, Yi Dong, Hua-Nan Wang, Yangyan Li, Gang Chen*, Access to benzene-modified 2^nd generation strigolactams and GR24 by merging C-H olefination with decarboxylative Giese cyclization, Org. Biomol. Chem., 2021, 19, 7141. 

(11) Yangyan Li#, Le Tu#, Xin Ma, Huan Chen, Yifan Fan, Qiang Zhou, Yao Sun*, Engineering a Smart Nanofluidic Sensor for High-performance Peroxynitrite Sensing Through a Spirocyclic Ring Open/Close Reaction Strategy, ACS Sens., 2021, 6, 3, 808.

(10)  Qingying Ouyang, Le Tu, Yi Zhang, Huan Chen, Yifan Fan, Yingfeng Tu*, Yangyan Li*, and Yao Sun*, Construction of a Smart Nanofluidic Sensor through a Redox Reaction Strategy for High-Performance Carbon Monoxide Sensing, Anal. Chem., 2020, 92, 14947. 

(9)  Xinsheng Xiao*, Sanping Huang, Shanshan Tang, Guokai Jia, Guangchuan Ou and Yangyan Li*, Ligand-free, Quinoline N-assisted Copper-catalyzed Nitrene Transfer Reaction to Synthesize 8-quinolylsulfimides, J. Org. Chem., 2019, 84, 7618.

(8)  Qingwen Gui, Kang Han, Zhuoliang Liu, Zhaohong Su, Xiaoli He, Hongmei Jiang*, Bufan Tian and Yangyan Li*, E-Selective synthesis of vinyl sulfones via silver-catalyzed sulfonylation of styrenes, Org. Biomol. Chem., 2018, 16, 5748. 

(7) Yangyan Li, Xiang Chen, Xiaoming Chen and Xiao Shen*, Organophosphine-Catalyzed [4C+X] Annulations, Molecules, 2018, 23, 3022. 

(6) Yangyan Li, Chao-Ze Zhu, Junliang Zhang*, Gold-Catalyzed [4+3] Cycloaddition/C–H Functionalization Cascade: Regio- and Diastereoselective Route to Cyclohepta[b]indoles. Eur. J. Org. Chem., 2017, 6609. 

(5) Yangyan Li, WenboLi, Junliang Zhang*, Gold-Catalyzed Enantioselective Annulations. Chem. Eur. J., 2017, 23, 467.

(4) Yangyan Li, Xiao Su, Wei Zhou, Wenbo Li, Junliang Zhang*, Amino Acid Derived Phosphine-Catalyzed Enantioselective 1,4-Dipolar Spiroannulation of Cyclobutenones and Isatylidenemalononitrile. Chem. Eur. J., 2015, 21, 4224.  

(3) Xiao Su#, Wei Zhou#, Yangyan Li, Junliang Zhang*, Design, Synthesis, and Application of a Chiral Sulfinamide Phosphine Catalyst for the Enantioselective Intramolecular Rauhut-Currier Reaction. Angew. Chem. Int. Ed., 2015, 54, 6874.

(2) Maomao He, Chunrong Qu, Bingbing Ding, Hao Chen, Yangyan Li, Guofu Qiu, Xianming Hu, Xuechuan Hong*, Total Synthesis of (±)-8-Oxo-erythrinine, (±)-8-Oxo-erythraline, and (±)-Clivonine, Eur. J. Org. Chem., 2015, 15, 3240. 

(1) Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with α-amino acid esters. Green Chem., 2011, 13, 2723.

(1) 陈刚；姚秋丽；孟江涛；李杨燕；一种3, 5-二氯苯胺的制备方法，2023-8-11，中国，CN119462392A。

(2) 陈刚; 李杨燕; 周昱彤; 一种C2-胺硼烷基取代的腺苷、腺苷酸及其类似物、制备方法和应用, 2024-1-5，中国，CN120271645A。

(3) 陈刚; 葛裕华; 李婉露; 赵芹; 谢若芊; 李杨燕; 肖国兰；一种烷基化核苷、核苷酸、寡核苷酸及其类似物的制备方法，2022-06-29，中国，CN117343119A。

(4) 肖新生; 李杨燕; 龚绍峰; 谢建伟; 胡姣 ; 一种芳并二氢吡咯[2, 3]并环丁烷类化合物及其合成方法，2020-12-16，中国，CN114634443A。

(5) 肖新生；李杨燕；欧光川；唐珊珊；刘芳；权婷；黄三萍；S-烷基-S-喹啉基-N-磺酰基氮硫叶立德化合物及其制备和应用，2019-02-26，中国，CN109810056A。（已授权）

(6) 唐珊珊；肖新生；李杨燕；一种催化转移氢化硝基环己烷制备环己酮肟的方法，2018-07-31，中国，CN109160887A。（已授权）

(7) 张俊良；宿晓；周伟；李杨燕；一种手性叔膦化合物及其全构型、制备方法和应用，2015-03-11，中国，CN104817591A。（已授权）